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          来 源:科学人才网


          牛津大学(University of Oxford;勋衔:Oxon或Oxf),简称“牛津”(Oxford),位于英国牛津,是一所公立研究型大学,采用传统学院制。是罗素大学集团成员,被誉为“金三角名校”和“G5”之一。牛津大学的具体建校时间已不可考,但有档案明确记载的最早的授课时间为1096年,之后在1167年因得到了英国王室的大力支持而快速发展。

          MRC Postdoctoral Fellow

          University of Cambridge

          MRC Postdoctoral Fellow

          The University of Cambridge wishes to appoint a postdoctoral scientist to join Dr Julien Prudent's research group in the MRC Mitochondrial Biology Unit in Cambridge.

          The postholder will work within a programme focussed on understanding mitochondrial dynamics and membrane contact sites as key regulators of cell fate decisions. Mitochondria form a dynamic and connected network, which is constantly remodelled by cycles of membrane fission and fusion. These dynamic transitions are not only required to ensure a proper mitochondrial function but also to respond to cellular needs and adapt to the metabolic state of the cell. To execute cellular functions, mitochondria also establish membrane contact sites with other organelles, including the endoplasmic reticulum, peroxisomes, trans-Golgi network vesicles and lysosomes. These organelle membrane contact sites are hotspots for metabolites flux and tightly regulate mitochondrial architecture. While defects in mitochondrial morphology or contact sites have been associated with human diseases, the molecular mechanisms linking mitochondrial membrane remodelling to cell fate decisions are not fully understood.

          The goal of the project is i) to apply cutting-edge microscopy methods coupled to biochemical analysis to study the molecular mechanisms regulating mitochondrial morphology, ii) to apply this approach to investigate how mitochondria-organelle contact sites drive mitochondrial membrane remodelling and mtDNA dynamics, and iii) to elucidate the relevance of these events to the cell death and survival pathways, as well as to inflammation and to human disease.

          Candidates will have (or be about to be awarded) a PhD in biological sciences, and a track record of related research achievements. Knowledge of organelle biology, membrane dynamics and experience of microscopy are essential.

          This is a three year training programme post which will terminate three years from your start date. On this date your employment will terminate without need for further notice.

          The MRC Mitochondrial Biology Unit is a world-renowned centre for research in respiratory enzymes. Additional information can be found at www. mrc- mbu.cam.ac.uk.

          Closing Date: 8th January 2023

          Interview Date: To be confirmed

          Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

          Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

          Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

          Please quote reference SM34723 on your application and in any correspondence about this vacancy.

          The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

          The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

          Further information

          Further Particulars


          MRC Mitochondrial Biology Unit








          16 December 2022

          Closing date

          8 January 2023

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